Winfried ELIS,Seth ETTENBERG,Andrew Paul GARNER,Nicole HAUBST,Heather Adkins HUET,Christian Carsten Silvester KUNZ,Elizabeth Anne REISINGER SPRAGUE,Qing SHENG
申请号：
US13693347
公开号：
US20130251703A1
申请日:
2012.12.04
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to antibodies or fragments thereof that bind to a non-linear epitope within domain 3 of the HER3 receptor and inhibit both ligand-dependent and ligand-independent signal transduction. The invention also relates antibodies or fragments thereof that bind to amino acid residues within domains 3-4 of HER3 and inhibit both ligand-dependent and ligand-independent signal transduction； and compositions and methods of use of such antibodies or fragments thereof.
