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Bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, snc disorders and autoimmune inflammation
专利权人:
4SC DISCOVERY GMBH
发明人:
JOHANN LEBAN,MIRKO ZAJA
申请号:
BR112014032581
公开号:
BR112014032581A2
申请日:
2013.06.27
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
abstract the invention relates to a compound of the general formula (i) or a physiologically functional derivative, solvate or salt thereof, wherein a bond is alkyl or alkoxy optionally substituted with one or more r '' as defined herein, * -n (r '' ') co-, * -con (r' '') -, * -n (r '' ') con (r' '') -, -s-, -so-, * -n ( r '' ') -, * -n (r' '') co-, * -con (r '' ') -, -co-, * -coo-, * -ooc-, * -so2n (r' '') -, -so2, or * -n (r '' ') - so2-, wherein r' '' is as defined here and * specifies the point of attachment to x; x is aryl, cycloalkyl, aralkyl, heterocyclyl or heteroaryl, which may be substituted with one or more further described herein; l is a bond or * -n (rn) co-, * -con (rn) -, * -n (rn) -, * -c = n (rn) -, * -n (rn) -alkyl-, * -alkyl-n (rn) -, * -n (rn) with (rn) -, * -co-, * -so2-, alkyl, * -alkyl-o-alkyl-, * -nco-ch = ch -, * -ch = ch-meet-, * -so2n (rn) -, * -n (rn) so2-, or heterocyclyl, wherein * specifies the point of attachment to x; y is h, alkyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heteroaryl, which may be substituted with one or more further described herein; and r and rn are further described herein; as well as their use as a medication, a pharmaceutical composition including them, a method of treatment or prevention of a medical condition, entailing the administration thereof, and the use thereof in a manufacture of a medicine for a treatment or prevention of a medical condition, particularly autoimmune inflammatory disorders, cns disorders, sleeping disorders, or proliferative diseases including cancer. the invention further relates to a specific process for the preparation of said compounds. ______________________________ abstract translation "bifluorodioxalane-amino-benzimidazole kinase inhibitors for the treatment of cancer, snc disorders and autoimmune inflammation". The present invention relates to a compound of the general formula (I) or a physiologically functional salt, solvate or derivative thereof, (i) wherein a is a bond, al
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