SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES

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专利权人:

ABBVIE INC.

发明人:

HEXAMER, LAURA,SONG, XIAOHONG,TAO, ZHI-FU,PARK, CHANG, H,MANTEI, ROBERT, A,KUNZER, AARON, R,DOHERTY, GEORGE, A,WANG, LE,MCCLELLAN, WILLIAM, J,SOUERS, ANDREW, J,DING, HONG,HASVOLD, LISA,SULLIVAN, GERAR

申请号：

NZ59280109

公开号：

NZ592801A

申请日:

2009.12.04

申请国别(地区):

NZ

年份:

2013

代理人:

摘要：

592801 Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BCL-2 or BCL-XL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic BCL-2 protein. Examples of compounds of formula (I) include: 4-(4-((4-chloro-1,1-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2Hpyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-phenoxybenzamide 4-(4-((4-chloro-1,1-biphenyl-2-yl)methyl)piperazin-1-yl)-2-phenoxy-N-((4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)benzamide 4-(4-((4-chloro-1,1-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(phenylthio)benzamide 4-(4-((4-chloro-1,1-biphenyl-2-yl)methyl)piperazin-1-yl)-2-(phenylthio)-N-((4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)benzamide.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/