HEXAMER LAURA,SONG XIAOHONG,TAO ZHI-FU,PARK CHANG H,MANTEI ROBERT A,KUNZER AARON R,DOHERTY GEORGE A,WANG LE,MCCLELLAN WILLIAM J,SOUERS ANDREW J,DING HONG,HASVOLD LISA,SULLIVAN GERARD M,WANG XILU,PETRO
申请号：
NZ61430509
公开号：
NZ614305A
申请日:
2009.12.04
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are compounds of formula (I) which inhibit the activity of anti-apoptotic BCL-2 or BCL-XL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic BCL-2 protein. Examples of compounds of formula (I) include: 4-(4-((4&rsquo-chloro-1,1&rsquo-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(2-phenylethyl)benzamide 2-(benzylamino)-4-(4-((4&rsquo-chloro-1,1&rsquo-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)benzamide 4-(4-((4&rsquo-chloro-1,1&rsquo-biphenyl-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-((tetrahydro-2H-pyran-4-ylmethyl)amino)phenyl)sulfonyl)-2-(phenoxymethyl)benzamide 4-{ 4-[2-(3-azabicyclo[3.2.2]non-3-yl)benzyl]piperazin-1-yl} -2-phenoxy-N-({ 4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]-3-[(trifluoromethyl)sulfonyl]phenyl} sulfonyl)benzamide 4-{ 4-[2-(3-azabicyclo[3.2.2]non-3-yl)benzyl]piperazin-1-yl} -2-phenoxy-N-({ 4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)benzamide 4-{ 4-[2-(3-azabicyclo[3.2.2]non-3-yl)benzyl]piperazin-1-yl} -N-({ 4-[(3-morpholin-4-ylpropyl)amino]-3-nitrophenyl} sulfonyl)-2-phenoxybenzamide 4-(4-{ 2-[(4R,7S)-2,3,3a,4,7,7a-hexahydro-1H-4,7-methanoinden-5-yl]benzyl} piperazin-1-yl)-N-({ 3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl} sulfonyl)-2-phenoxybenzamide.
