An agent for screening at least one agent selected from the group consisting of agents for increasing or decreasing the number of cells expressing Frizzled 3 cells, agents for preventing or treating diabetes, agents for preventing or treating insulinoma, and agents for promoting insulin secretion or secretion. Screening agent, screening kit, and screening method
PROBLEM TO BE SOLVED: To provide a cell number reducing agent for frizzled 3 expressing cells, or an agent for preventing or treating insulinoma. SOLUTION: At least one agent selected from the group consisting of an agent for increasing or decreasing the number of frizzled 3 expressing cells, an agent for preventing or treating diabetes, an agent for preventing or treating insulinoma, and an insulin secretagogue or an inhibitor of secretion. Screening agent for screening, method for screening cell number increasing agent or cell reducing agent for frizzled 3 expressing cell including step of using frizzled 3 expressing cell and frizzled 3 protein or gene, and cell number increasing agent for frizzled 3 expressing cell , A prophylactic or therapeutic agent for diabetes, an insulin secretagogue, a cell number reducing agent for frizzled 3 expressing cells, and a prophylactic or therapeutic agent for insulinoma. [Selection diagram] FIG.【課題】フリズルド３発現細胞の細胞数低下剤、又はインスリノーマ予防、若しくは治療剤の提供。【解決手段】フリズルド３発現細胞の細胞数増加剤若しくは低下剤、糖尿病予防若しくは治療剤、インスリノーマ予防若しくは治療剤、及びインスリン分泌促進剤若しくは分泌抑制剤よりなる群から選択される少なくとも１つの剤をスクリーニングするためのスクリーニング剤、及びフリズルド３発現細胞とフリズルド３タンパク質若しくは遺伝子を用いる工程を含むフリズルド３発現細胞の細胞数増加剤又は低下剤のスクリーニング方法、並びに、フリズルド３発現細胞の細胞数増加剤、糖尿病予防若しくは治療剤、インスリン分泌促進剤、フリズルド３発現細胞の細胞数低下剤、及びインスリノーマ予防若しくは治療剤。【選択図】図６
