AKIHIRO HASHIMOTO,AVINASH PHADKE,JASON ALLAN WILES,MILIND DESHPANDE
申请号：
BR112015025716
公开号：
BR112015025716A2
申请日:
2014.04.14
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract deuterated nucleoside analogs of formula (i) and the pharmaceutically acceptable salts thereof are provided by this disclosure formula (i) the variables, eg, b1, y, r1, r2, r3, r3, r4, r5, r6, r7, r8, and r9 carry definitions set forth in the disclosure. compounds of formula (i) are deuterated at one or more positions and the deuterium enrichment at each deuterated position is at least 50%. compounds and salts of formula (i) are useful for treating viral infections, including hcv infections. __________________ translation of the abstract summary patent: "Deuterium-nucleoside prodrugs useful for the treatment of hcv". Deuterium-nucleoside analogues of formula (I) and their pharmaceutically acceptable salts are provided by this disclosure of formula (I). variables, for example, b1, y, r1, r2, r3, r3 ', r4, r5, r6, r7, r8 and r9, carry the definitions given in the disclosure. The compounds of formula (I) are deuterium in one or more positions and the deuterium enrichment in each of the deuterium positions is at least 50%. The compounds and salts of formula (I) are useful for treating viral infections, including hcv infections.abstract deuterated nucleoside analogs of formula (i) and the pharmaceutically acceptable salts thereof are provided by this disclosure formula (i) the variables, e.g., b1, y, r1, r2, r3, r3', r4, r5, r6, r7, r8, and r9 carry definitions set forth in the disclosure. compounds of formula (i) are deuterated at one or more positions and the deuterium enrichment at each deuterated positions is at least 50%. compounds and salts of formula (i) are useful for treating viral infections, including hcv infections. __________________ tradução do resumo resumo patente de invenção: "pró-fármacos de nucleosídeo sub-metidos a deutério úteis para o tratamento de hcv". análogos de nucleosídeo submetidos a deutério de fórmula (i) e os seus sais farmaceuticamente aceitáveis são fornecidos por es-ta divulgação da fórmula (i). as variáveis, por exemplo, b1, y
