#$%^&*AU2013200538A120130221.pdf#####ABSTRACT Provided herein is a method of reversing or preventing a target cells resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.1/22 02% MDA-231 3.9. UL-3C 10- i0 104, 10 PE Pr2 B ~TRAIL-R2---100 100>l 75- 75. so- 50. 6 25 - 25 2- TR-9 -T AS CO -*-2E12 -k2I I TRAIL -*-TRAIL _______ C Doses (nglml) 100- 100> 75 75M 50. 50. = 25- 25O -0-non-induced -0- non-induced -0-inced-9- induced 0 0 TRA-8 (nglml) FIG. 1
