Katherine Bowdish,Anke Kretz-Rommel,Mark Renshaw,Bing Lin,Jean de Silva Correia,Roger Ferrini,Elise Chen
申请号：
US13190914
公开号：
US20120021995A1
申请日:
2011.07.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Agonists for TRAIL death receptors including polypeptides that bind to TRAIL death receptor TRAIL-R1 (DR4) and/or TRAIL-R2 (DR5) and optionally having a multimerizing, e.g. trimerizing domain. Agonists are described that do not bind to TRAIL decoy receptors. The multimerizing domain may be derived from human tetranectin. The agonists can induce apoptosis in pathogenic cells expressing a TRAIL death receptor. Pharmaceutical compositions are described for treating diseases associated with cells expressing DR4 and DR5, such as tumor cells. Methods for selecting polypeptides and preparing multimeric complexes.
