T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof

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专利权人:

National University of Singapore

发明人:

KAMIYA, Takahiro,CAMPANA, Dario

申请号：

AU2018313939

公开号：

AU2018313939A1

申请日:

2018.08.09

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present invention provides compositions comprising a protein expression blocker or PEBL comprising a target-binding molecule and localizing domain, and methods of using such compositions in cancer therapy. PEBLs are useful as a blockade of expression of target surface receptors (peptides or antigens) in immune cells. Also provided herein are CD3/TCRαβ- deficient T cells and CD3/TCRαβ-deficient chimeric antigen receptor T cells that express such PEBLs.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/