LYMPHOCYTES T RECEPTEURS D'ANTIGENES CHIMERIQUES DEFICIENTS EN RECEPTEURS DE LYMPHOCYTE T ET PROCEDES D'UTILISATION CORRESPONDANTS

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专利权人:

NATIONAL UNIVERSITY OF SINGAPORE

发明人:

KAMIYA, TAKAHIRO,CAMPANA, DARIO

申请号：

CA3071282

公开号：

CA3071282A1

申请日:

2018.08.09

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present invention provides compositions comprising a protein expression blocker or PEBL comprising a target-binding molecule and localizing domain, and methods of using such compositions in cancer therapy. PEBLs are useful as a blockade of expression of target surface receptors (peptides or antigens) in immune cells. Also provided herein are CD3/TCRaß- deficient T cells and CD3/TCRaß-deficient chimeric antigen receptor T cells that express such PEBLs.

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中国工程科技知识中心

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http://www.ckcest.cn/home/