#$%^&*AU2013204922A120140710.pdf#####ABSTRACT Provided herein are therapeutic polypeptides, e,g., chimeric antigen receptors, able to direct an imune cell, e a T lymphocyte to a target antigen, and able to cause the T cell to proliferate or to kill cells displaying the antigen when the antigen binds to the polypeptide, wherein the polypeptides comprise a transmembrane domain from a T cell coinhibitory protein such as CTLA4 or PDi, Also provided herein are T lymphocytes expressing the polypeptides, and use of such T lymphocytes to treat diseases such as cancer,
