#$%^&*AU2011259844A120120119.pdf#####ABSTRACT Provided herein is a method of reversing or preventing a target cells resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.1 / 22 02% MDA-231 3.2% UL-3C lam_ I-. b 1050 Wa IO i00 10p I0 0 0 10 0 PEz PE B ~TRAIL-R2--100. 100>~75- 75~50 50= 25- 5 0 4-TR-TRA25 .) -A--2 E12 *2I a-U-TRAIL 0 -U-TRAIL C Doses (nglml) 4.~75- 7550- 50. = 25- 25-41, - non-induced -0-n-induced 01-0S- induced 0 -0-induced N ~. N V 1 TRA-8 (nglml) FIG. 1
