Anke Kretz-Rommel;Mark Renshaw;Martha Wild;Katherine S. Bowdish;Bing Lin
发明人:
Katherine S. Bowdish,Anke Kretz-Rommel,Mark Renshaw,Bing Lin,Martha Wild
申请号：
US13359211
公开号：
US20120135938A1
申请日:
2012.01.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Agonists for TRAIL death receptors including polypeptides having a multimerizing, e.g. trimerizing, domain and a polypeptide sequence that binds to at least one of TRAIL death receptors TRAIL-R1 and TRAIL-R2. Agonists are described that do not bind to TRAIL decoy receptors. The multimerizing domain may be derived from human tetranectin. The agonists can induce apoptosis in pathogenic cells expressing a TRAIL death receptor. Pharmaceutical compositions are described for treating diseases associated with cells expressing DR4 and DR5, such as tumor cells. Methods for selecting polypeptides and preparing multimeric complexes.
