BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM;MONASH UNIVERSITY;UNIVERSITY OF WASHINGTON;GLAXOSMITHKLINE INVESTIGACION Y DESARROLLO, S.L.;MMV MEDICINES FOR MALARIA VENTURE
Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.