Board of Regents, The University of Texas System;Glaxosmithkline Investigacion y Desarrollo, S.L.;Monash University;MMV Medicines for Malaria Venture;University of Washington
Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.text