COE JOTHAM WADSWORTH,DEHNHARDT CHRISTOPH MARTIN,JONES PETER,KORTUM STEVEN WADE,SABNIS YOGESH ANIL,WAKENHUT FLORIAN MICHEL,WHITLOCK GAVIN ALISTAIR
申请号：
ARP120102730
公开号：
AR087348A1
申请日:
2012.07.26
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compositions containing such compounds and the uses of such compounds in the treatment of several diseases, especially Asthma and COPD.Claim 1: a compound characterized by the formula (1) or a pharmaceutically acceptable salts thereof, or a pharmaceutically acceptable solvate of the compound or pharmaceutically acceptable salt: Halo, where R1 is alkyl； R2 is C1 - 6 optionally substituted with one or more S Atoms of Fluorine； X is a Link -, co -, - or - CH2 - SO2 -； R3 is aril1, het1 or het2,Each of which is optionally substituted with one Substituent and R4 and / or 1 - 4 substituents each selected independently of R5； n is 1 or 2； aril1 is phenyl or naphthyl； het1 is (i) an Aromatic heterocycle of 6 members that contains 1 - 3 (OR N Atoms (ii) a heterocycle Aromatic Member 5 contains (a) 1 - 4 (b) of Atoms or Atom or 1 or 0 - 3 s and N Atoms； IT2 is a bicyclic Aromatic heterocycle (i) 10 Member containing 1 - 4 Atoms of N or (ii) a bicyclic Aromatic heterocycle containing 9 members (1 - 4) n or (b) Atoms or Atom or 1 s and 0 - 3 Atoms of N or (iii) a bicyclic Aromatic heterocycle of 8 members co NTiene (1 - 4) n or (b) Atoms or Atom 1 and 1 - 3 or s Atoms of N or (c) 2 or 0 - 2 or s Atoms and N AtomsAnd it is a Link - or or -； R4 or R5 is het3 il2ra； 6 is C1 - C3 alkyl, cycloalkyl Halo, - 8, - CN, - or6 nr7r8 SR6, -, -, - sor9 so2r9 cor6, -, -, - ocor6 coor6 nr6cor6, -, -, - conr7r8, - nr6so2r9 so2nr7r6 nr6conr7r8, -, -, - or - nr6coor9 nr6so2nr7r8； R6 is H, alkyl or cycloalkyl C1 - C3 6 - 8, the rent is C1 - 6 To optionally substituted cycloalkyl with Halo or C3 - 8； R7 and R8 are independently H (a),C1 C3 alkyl or cycloalkyl - 8 - 8 - 6, the rent is optionally substituted with C1 - nr10r11 R10 and R11, where C1 alkyl - or 6 are taken together with the nitrogen Atom to which they are United to form a Heterocyclic Ring of 4 -, 5 - or 6 - saturated Member containing 1 - 2 Atoms Particulate 1 Oxygen or nitrogen Atom and one Oxygen Atom.The Heterocyclic ring is optio
