A compound of the formula (I): ** Formula ** in which X and Z are independently selected from the group consisting of hydrogen, (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl , unsubstituted or substituted cycloalkyl (C3-C8), cycloalkyl (C3-C8) -alkyl (C1-C8) or unsubstituted or substituted -alkyl (C2-C8), cycloalkenyl (C5-C8) unsubstituted or substituted, cycloalkenyl (C5-C8) -alkyl (C1-C8) or - unsubstituted or substituted (C2-C8) alkenyl, bicycloalkyl (C6-C10), unsubstituted or substituted heterocycloalkyl, heterocycloalkyl (C1-C8) alkyl or -alkenyl ( C2-C8) unsubstituted or substituted, unsubstituted or substituted aryl, (C1-C8) arylalkyl or unsubstituted or substituted (C2-C8) alkenyl, unsubstituted or substituted heteroaryl, (C1-C8) heteroaryl or -alkenyl ( C2-C8) unsubstituted or substituted, halo, cyano, -CORa, - CO2Ra, -CONRaRb, -CONRaNRaRb, -SRa, -SORa, -SO2Ra, -SO2NRaRb, nitro, -NRaRb, -NRaC (O) Rb, - NRaC (O) NRaRb, -NRaC (O) ORa, -NRaSO2Rb, - NRaSO2NRaRb, -NRaNRaRb, -NRaNRa C (O) Rb, -NRaNRaC (O) NRaRb, -NRaNRaC (O) ORa, -ORa, -OC (O) Ra, and - OC (O) NRaRb； Y is H or halo； R1 is (C1-C8) alkyl, (C2-C8) alkenyl, (C2-C8) alkynyl, unsubstituted or substituted cycloalkyl (C3-C8) -alkyl (C3-C8) -alkyl (C1-C8) or -alkenyl (C2-C8) unsubstituted or substituted, cycloalkenyl (C5-C8) unsubstituted or substituted, cycloalkenyl (C5-C8) -alkyl (C1-C8) or -alkenyl (C2-C8) unsubstituted or substituted, bicycloalkyl (C6 -C10), unsubstituted or substituted heterocycloalkyl, heterocycloalkyl (C1-C8) alkyl or unsubstituted or substituted (C2-C8) alkyl, unsubstituted or substituted aryl, aryl (C1-C8) alkyl or (C2-alkenyl) -C8) unsubstituted or substituted, unsubstituted or substituted heteroaryl, heteroaryl (C1-C8) alkyl or unsubstituted or substituted (C2-C8) alkenyl, -CORa, -CO2Ra, - CONRaRb, -CONRaNRaRb； R3 is hydrogen, (C1-C8) alkyl, cyano, trifluoromethyl, -NRaRb, or halo； R6 is selected from the group consisting of hydrogen, halo, (C1-C8) alkyl, (C2-C8) alkenyl, -B
