HOPKINS, Brian T.,CONLON, Patrick,CHAN, Timothy R.,JENKINS, Tracy J.,CAI, Xiongwei,HUMORA, Michael,SHI, Xianglin,MILLER, Ross A.,THOMPSON, Andrew
申请号：
ES13800042
公开号：
ES2684268T3
申请日:
2013.06.07
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: each R1 is independently hydrogen, an optionally substituted C1-6 aliphatic group, a 3-7 membered, optionally substituted monocyclic heterocyclic group , or an optionally substituted heterocyclylalkyl group having 3-7 carbon atoms and 1-3 heteroatoms independently selected from nitrogen, oxygen or sulfur； or two R1 groups are taken together with their intervening atoms to form a 3-7 membered, optionally substituted monocyclic, saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen or sulfur； wherein the optionally substituted groups can be substituted with halogen, -NO2, -CN, -OR, -SR, -N (R) 2, -C (O) R, -CO2 R, -N (R) C (O) OR, -C (O) N (R) 2, -OC (O) R, -N (R) C (O) R, -S (O) R, -S (O) 2 R, or -S ( O) 2 N (R) 2； each R is independently hydrogen or a C1-6 aliphatic group； or two R groups attached to the same nitrogen are taken together with their intervening atoms to form a 3-7 membered, optionally substituted monocyclic, saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms, wherein any second heteroatom is independently selected of nitrogen, oxygen or sulfur； Ring A is ** Formula ** R2 is -Cl or -F； and R3 is -CF3, -OCF3, or -F.Un compuesto de fórmula I:**Fórmula** o una sal farmacéuticamente aceptable de este, en donde: cada R1 es independientemente hidrógeno, un grupo alifático C1-6 opcionalmente sustituido, un grupo heterocíclico monocíclico, de 3-7 miembros, opcionalmente sustituido, o un grupo heterociclilalquilo opcionalmente sustituido que tiene 3-7 átomos de carbono y 1-3 heteroátomos seleccionados independientemente de nitrógeno, oxígeno o azufre； o dos grupos R1 se toman junto con sus átomos interventores para formar un anillo heterocíclico monocíclico, saturado o parcialmente insaturado, de 3-7 miembros, opcionalmente sustituido que tiene 1-2 heteroátomos seleccionados in
