HOPKINS BRIAN T.,CONLON PATRICK,CHAN TIMOTHY R.,JENKINS TRACY J.,CAI XIONGWEI,HUMORA MICHAEL,SHI XIANGLIN,MILLER ROSS A.,THOMPSON ANDREW
申请号：
NZ70271513
公开号：
NZ702715A
申请日:
2013.06.07
申请国别(地区):
NZ
年份:
2016
代理人:
摘要：
The present invention provides compounds of formula I and compositions thereof which are useful as inhibitors of Bruton&rsquos tyrosine kinase and which exhibit desirable characteristics for the same, wherein each R1 is independently hydrogen, an optionally substituted C1-6 aliphatic group, an optionally substituted 3-7 membered monocyclic heterocyclic group, or an optionally substituted heterocyclylalkyl group having 3-7 carbon atoms and 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur or two R1 groups are taken together with their intervening atoms to form an optionally substituted 3-7 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur Ring A is wherein R2 is -Cl or &ndashF and R3 is &ndashCF3, -OCF3, or &ndashF.
