FIELD: pharmacology.SUBSTANCE: compounds can be used as therapeutically active substances for the treatment of inflammatory and/or autoimmune conditions selected from rheumatoid arthritis and asthma. In formula IA is phenyl, n is 1 or 2, R1 is CH2NHC(=O)R1' or CH2NHC(=O)CH2NHR1', where n is 1. And one R1 is halogen, and the other R1 represents CH2NHC(=O)R1' or CH2N(CH3)C(=O)R1', when n is 2. R1' represents a lower alkoxy group, phenyl, an unsaturated or partially unsaturated 8-9-membered bicyclic heterocycle containing 1-2 heteroatoms in the bicyclic system selected from nitrogen and sulfur, or a 4-6-membered monocyclic heteroaryl with 1-3 heteroatoms selected from nitrogen, oxygen and sulfur, or a 4-5-membered heterocycloalkyl containing oxygen or nitrogen atoms as heteroatoms, optionally substituted by one or more R1". Each radical R1" is an independent lower alkyl, halogen, 3-6-membered cycloalkyl, 4-membered heterocycloalkyl with an oxygen atom as a heteroatom, lower alkyl-4-membered heterocycloalkyl with an oxygen atom as a heteroatom, oxo group, cyano-lower alkyl, hydroxyl-lower alkyl or lower alkoxy group. R2 is H, R3 or R4. R3 represents C(=O)OR3', C(=O)R3' or C(=O)NH(CH2)2R3'. R3' is H, a lower alkyl, 6-membered heterocycloalkyl with 1-2 heteroatoms selected from nitrogen and oxygen, an amino group or OH. R4' is a pyrasolyl possibly substituted with R4'. And R4' is a methyl, CH2-CH2N(CH3)2, CH2C(=O)OCH2CH3, CH2C(=O)OH or CH2CH2OH.EFFECT: increased efficiency of treatment.18 cl, 2 tbl, 51 exИзобретение относится к новому соединению формулы I или его фармацевтически приемлемой соли, которые обладают свойствами ингибитора тирозинкиназы Брутона. Соединения могут быть использованы в качестве терапевтически активного вещества для лечения воспалительного и/или аутоиммунного состояния, выбранного из ревматоидного артрита и астмы. В формуле IА представляет собой фенил； n равно 1 или 2； R1 представляет собой CH2NHC(=O)R1' или CH2NHC(=O)CH2NHR1', когда n равно 1； и од
