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Pyrrole compounds as ERK protein kinase inhibitors and pharmaceutical compositions containing those compounds
专利权人:
Vertex Pharmaceuticals Incorporated
发明人:
Martinez-Botella, Gabriel,Hale, Michael,Maltais, François,Tang, Qing,Straub, Judith
申请号:
ES14163944
公开号:
ES2651439T3
申请日:
2005.05.13
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound, wherein the compound is a compound of formula II: ** Formula ** or a pharmaceutically acceptable salt thereof, in which: R1 is an aliphatic C1-6 group, in which R1 is optionally substituted with up to 2 groups independently selected from -OR, -OR4 or -C1-3 haloalkyl; each R is independently hydrogen or aliphatic C1-6; each R2 is independently R, fluoro or chloro; m is 0, 1 or 2; R3 is hydrogen, C1-3 aliphatic, fluoro or chloro; each R4 is independently hydrogen, -C (R) 2O-R5 or R5, provided that at least one R4 or R8 group is not hydrogen; each R5 is independently -C (O) R6, -C (O) OR6, -C (O) -Q-R6, -C (O) - (CH2) nC (O) OR6, -C (O) - ( CH2) n- C (O) N (R7) 2, -C (O) - (CH2) n-CH (R6) N (R7) 2, -P (O) (OR6) 2; each R6 is independently hydrogen, an optionally substituted aliphatic C1-6 group or a saturated, partially unsaturated or fully unsaturated, optionally substituted 5-8 membered ring, having 0-4 heteroatoms independently selected from nitrogen, oxygen or sulfur; each R7 is independently hydrogen, -C (O) R6, -C (O) OR6, -S (O) 2R6, -OR6, an optionally substituted aliphatic C1-6 group or a saturated, partially unsaturated 5-8 membered ring or totally unsaturated, optionally substituted, which has 0-4 heteroatoms independently selected from nitrogen, oxygen or sulfur, or: two R6 in the same nitrogen atom taken together with the nitrogen atom to which they are attached form a ring of 4-7 saturated, partially unsaturated or fully unsaturated members having 1-3 heteroatoms in addition to the nitrogen atom, independently selected from nitrogen, oxygen or sulfur; each n is 0-6; Q is an optionally substituted C1-10 alkylidene chain in which zero to four methylene units of Q are independently replaced by -O-, -N (R) -, -S-, -S (O) -, -S ( O) 2- or - C (O) -; and R8 is hydrogen or -C (R) 2O-R5.Un compuesto, en el que el compuesto es un compuesto de fórmula II:**Fórmula** o una de sus sales farmacéuticamente aceptables, en la que: R1 es un grupo C1-6 alifátic
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