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Mannose derivatives to treat bacterial infections
专利权人:
Vertex Pharmaceuticals Incorporated
发明人:
RAMTOHUL, Yeeman,DAS, Sanjoy,CADILHAC, Caroline,REDDY, Thumkunta,VAILLANCOURT, Louis,GALLANT, Michel,LIU, Bingcan,DIETRICH, Evelyne,VALLEE, Frederic,MARTEL, Julien,POISSON, Carl
申请号:
ES13818136
公开号:
ES2685975T3
申请日:
2013.12.18
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compound of formula ID, or pharmaceutically acceptable salt thereof: ** Formula ** wherein the H ring is an optionally substituted 5-6 membered monocyclic aromatic ring that optionally has 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur; or an 8-12 membered bicyclic aromatic ring optionally having 1-6 heteroatoms selected from oxygen, nitrogen, or sulfur; or a 10-14 membered tricyclic aromatic ring optionally having 1-6 heteroatoms selected from oxygen, nitrogen, or sulfur, JH is halogen, -CN, -NO2, XJ, QJ, or XJ-QJ or two JH, groups attached to the same carbon atom, together with the carbon atom to which they are attached, optionally form -C>; = N-OH, -C (O) -, or HH ring; the HH ring is a 3-8 membered saturated monocyclic ring that has 0-2 heteroatoms selected from oxygen, nitrogen, or sulfur; optionally substituted with 1-4 cases of JHH; JHH is halo, CN, oxo, XJ, QJ, or XJ-QJ; XJ is a C1-C10 aliphatic, in which up to 4 methylene units of the C1-C10 aliphatic are optionally substituted with -O-, -NH, N (C1-C6 aliphatic), -S-, -C ( O) -, -C (>; = NOH) -, -S (O) -, -S (O) 2-, P, or P (O); XJ is optionally substituted with 0-6 cases of halo, OH, or C1-4 alkyl; or is optionally substituted with 0-1 cases of CN; QJ is a 3-7 membered saturated, completely unsaturated, partially unsaturated or monocyclic aromatic ring that optionally has 1-4 heteroatoms selected from oxygen, nitrogen, or sulfur; or a saturated, completely unsaturated, partially unsaturated or aromatic 8-12-membered ring optionally having 1-6 heteroatoms selected from oxygen, nitrogen, or sulfur; wherein each QJ is optionally substituted with 1-6 cases of halo, oxo, CN, or C1-6 alkyl, in which up to 2 methylene units of said C1-6 alkyl are optionally substituted with -O-, -NH, N (C1-C6 aliphatic), -S-, -C (O) -, -S (O) -, or -S (O) 2-.Compuesto de fórmula ID, o sal farmacéuticamente aceptable del mismo: **Fórmula** en el que el anillo H es un anillo aromático monocíclico de 5-6 miembros opci
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