TERRY AARON PANCHAL,ANDREW STEPHEN ROBERT JENNINGS,ELISABETTA ARMANI,MONIQUE BODIL VAN NIEL,NICHOLAS CHARLES RAY,LILIAN ALCARAZ
申请号：
ARP120104597
公开号：
AR089113A1
申请日:
2012.12.07
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
They are inhibitors of p38 MAPK, useful as anti-inflammatory agents in the treatment of respiratory tract diseases, among others. Claim 1: A compound characterized in that it is of formula (1) or a pharmaceutically acceptable salt thereof, wherein: W is a heteroatom selected from N or O, wherein N is substituted with hydrogen, C₁₋₆ alkyl or C₃₋₅ cycloalkyl；And it is selected from the group consisting of: a group -S (O) ₚ- where p is 0, 1 or 2； a group -O (CR³R⁴) ₙ-；a. One group - (cr8309；) (r8310)；1 group - No. 8311a；1 General Service (other level)One group - OC (o) NH -；And a group - OC (o) O -；R3,R830808,R83099 and r8310a are hydrogen, fluorine or c83218c83318326；Or R3 and r83088 respectively；or R⁵ and R⁶ may form together with the carbon atom to which a 3-6-membered saturated monocyclic carbocyclic ring is optionally substituted with a C₁₋₆ alkyl group,hydroxyl or halo； n is 0, 1, 2 or 3； R⁷ is hydrogen, C₁₋₆ alkyl,or C₃₋₇ cycloalkyl,where said C₁₋₆ alkyl,or C₃₋₇ cycloalkyl are optionally substituted with a C₁₋₃ alkyl group,C₃₋₆ cycloalkyl,1. Hydroxyl, cyanogen or halogen； R1 is a group selected from (2) to (4) formula；where R⁸ is - (alkylene Cquile) -NRARB, - (cycloalkylene C₃₋₇) -NRARB, -NRARB, N (RC) - (alkylene C₂₋₆) -NRARB, N (RC) - (cycloalkylene C₃₋₇ ) -NRARB, or -RC； RA and RB are in each case independently hydrogen, C₁₋₆ alkyl or C₃₋₇ cycloalkyl,wherein said C₁₋₆ alkyl and C₃₋₇ cycloalkyl are optionally substituted with a C₁₋₃ alkyl group,C₃₋₇ cycloalkyl,-ORD, -SRD, -NRERF, -CN or halo； alternatively, RA and RB may form together with the nitrogen atom to which a 5-11 membered saturated monocyclic or bicyclic ring system is attached wherein said saturated 5-11 membered monocyclic or bicyclic ring is optionally substituted with one or more -ORD, -CN, halo, C₁₋₆ alkyl or C₃₋₇ cycloalkyl groups,wherein said C₁₋₆ alkyl and C₃₋₇ cycloalkyl are optionally substituted with a C₁₋₃ alkyl group,C₃₋₇ cycloalkyl,-ORD, -CN or halo； and where, optionally, said 5-11 mem
