ДЕЛОНГ Митчелл А. (US),КВАЛНЕС Калла Линн (US),БОЙССИ Рэймонд (US)
申请号：
RU2014128022
公开号：
RU2014128022A
申请日:
2013.01.04
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. A chiral non-racemic compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein Z is selected from NR, S, O, SO and SO； R is selected from hydrogen and a C1-6 aliphatic group； X and X are independently selected from hydrogen, halogen, cyano, nitro an optionally substituted C1-6 aliphatic group, —OR, —SR, —N (R), —COOR, and —CON (R)； each R independently represents hydrogen or an optionally substituted C1-6 aliphatic group； IA and B independently represent a possibly substituted group selected from a C1-10 aliphatic group, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-8 membered saturated or partially unsaturated heterocyclic ring containing 1-2 heteroatoms, independently selected from nitrogen, oxygen and sulfur, phenyl, an 8-10 membered bicyclic aryl ring, a 5-6 membered heteroaryl ring containing 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur, or an 8-10 membered bicyclic heteroar a ring containing 1-4 heteroatoms independently selected from nitrogen, oxygen or sulfur； or A and B together with the atoms to which they are attached may form a possibly substituted saturated or partially unsaturated monocyclic or bicyclic ring containing 4-12 ring atoms and 0-2 heteroatoms independently selected from nitrogen, oxygen and sulfur. 2. A compound according to claim 1, wherein said compound has the formula I-a: wherein: n is 1, 2, 3, 4 or 5； each R is independently selected from hydrogen and a C1-6 aliphatic group； each R ′ is independently selected from hydrogen, a C1-6 aliphatic group and -OR, while each R is independently selected from hydrogen and a C1-6 aliphatic group. 3. The compound of claim 1, wherein the compound has the formula I-b: 4. The compound according to claim 1, wherein the compound has the formula I-c: 51. Хиральное нерацемическое соединение формулы (I):или его фармацевтически приемлемая соль, гдеZ выбран из NR, S, О, SO и SO；Rвыбран из водорода и С1-6 алифатической группы；Xи Хне
