JAMES P. DIZIO,ELIZABETH E. JOHNSON,ZHENG Z. WU,AMY PRESZLER PRINCE
申请号:
US15168270
公开号:
US20160271074A1
申请日:
2016.05.31
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and at least one pharmaceutically active compound which is susceptible to oxidative degradation; wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive, methods of making the composition, a transdermal drug delivery device using the composition, methods of making the device, and methods of delivery the pharmaceutically active compound are provided.