DIZIO JAMES P,WU ZHENG ZHI,JOHNSON ELIZABETH E,PRESZLER PRINCE AMY
申请号：
ZA201301336
公开号：
ZA201301336B
申请日:
2013.02.20
申请国别(地区):
ZA
年份:
2014
代理人:
摘要：
The present invention relates to a transdermal drug delivery device comprising:a transdermal adhesive composition comprising:an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers； andat least one pharmaceutically active compound which is susceptible to oxidative degradation； wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive；a backing sheet coated with the transdermal adhesive composition, wherein the transdermal adhesive composition coating covers at least a portion of a major surface of the backing sheet wherein any free radical initiator, if present in the adhesive, is present at a level of less than 20 ppm, based upon the total weight of the adhesive； andwherein less than 0.1% of antioxidant is present in the transdermal adhesive composition.
