The Broad Institute, Inc.;The Brigham and Women's Hospital, Inc.;Massachusetts Institute of Technology
发明人:
Chao Wang,Vijay K. Kuchroo,Aviv Regev,Gerd Meyer zu Hörste
申请号：
US16394747
公开号：
US20190345446A1
申请日:
2019.04.25
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The subject matter disclosed herein is generally directed to compositions and methods related to FAS-STAT1 interactions. Modulation of FAS-STAT1 interaction can be used to shift Th17-to-Th1 cell balance. The methods and cell compositions can be used for treating autoimmunity in a subject in need thereof. Cell compositions with altered FAS-STAT1 interactions can be used for adoptive cell transfer. The invention also relates to screening for agents capable of modulating FAS-STAT1 interactions.
