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ICOS critically regulates the expansion and function of inflammatory human Th17 cells
专利权人:
The Trustees of the University of Pennsylvania
发明人:
James L. Riley,Chrystal Paulos,Carl H. June,Bruce L. Levine
申请号:
US14823281
公开号:
US09994818B2
申请日:
2015.08.11
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The invention includes compositions and methods for generating and expanding therapeutic Th17 cells. The invention includes contacting T cells with a composition comprising a first agent that is capable of providing a primary activation signal to T cells and a second agent that is capable of activating ICOS on T cells in the presence of Th-17 polarizing agents.
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