YOON, Pyoung Oh,윤평오,KWON, Taewoo,권태우,PARK, Han Oh,박한오,KIM, Tae-Rim,김태림,BAE, Seon Joo,배선주,KO, Youngho,고영호,KIM, Han-Na,김한나,BAE, Seonjoo,배선주,LEE, Jiyoung,이지영,YUN, Sung Il,윤성일,PARK, Jun Hong,박준홍,JUNG, Jun
申请号：
KRKR2016/006363
公开号：
WO2016/204515A1
申请日:
2016.06.15
申请国别(地区):
WO
年份:
2016
代理人:
摘要：
The present invention relates to: a STAT3 gene specific siRNA a highly efficient double-helical oligo RNA structure including the same a pharmaceutical composition containing the same and a use thereof and, more particularly, to: a STAT3 gene specific siRNA a double-helical oligo RNA structure, which includes the same and has a structure in which hydrophilic materials and hydrophobic materials are bound to both ends of the double-helical RNA (siRNA), by using a simple covalent bond or a linker-mediated covalent bond, so as to be effectively transferred into a cell nanoparticles capable of being produced, in an aqueous solution, by hydrophobic interactions between the double-helical oligo RNA structures a method for producing the double-helical oligo RNA structure and a pharmaceutical composition for preventing or treating cancers, especially breast cancer, skin diseases including psoriasis, or inflammatory diseases, containing the double-helical oligo RNA structure. According to the present invention, the STAT3 specific siRNA and the composition for treating cancers, skin diseases, or inflammatory diseases, containing the double-helical oligo RNA structure including the same can achieve a therapeutic effect on cancers, especially breast cancer, skin diseases including psoriasis, or inflammatory diseases by inhibiting the expression of STAT3 with high efficiency without causing side effects, and thus the present invention can be useful in treating breast cancer, skin diseases, or inflammatory diseases for which there currently is no suitable therapeutic agent.Linvention concerne un ARNsi spécifique du gène STAT3 une structure doligo-ARN à double hélice hautement efficace comprenant celui-ci une composition pharmaceutique les contenant et une utilisation de ceux-ci. Elle concerne plus particulièrement un ARNsi spécifique de gène STAT3 une structure doligo-ARN à double hélice comprenant celui-ci et présentant une structure dans laquelle des matières hydrophiles et de m
