A SPECIFIC GENE RELATED TO RESPIRATORY DISEASE, DOUBLE-DESIGNED OLIGO-RNA CONSTRUCTION CONTAINING miRNA, AND CONTAINING ITS COMPOSITION FOR PREVENTION OR TREATMENT
ЧХЭ Чейук (KR),ПАК Хан О (KR),ЮН Пён О (KR),ХАН Борам (KR),КИМ Ми На (KR)
申请号：
RU2016103695
公开号：
RU2016103695A
申请日:
2014.07.04
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
The present invention relates to respiratory diseases, especially to gene specific siRNA related to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD), and a highly efficient double-helical oligo RNA structure containing the same, wherein the double-helical oligo RNA structure has a structure in which hydrophilic and hydrophobic materials are bonded at the both ends of the double-helical RNA (siRNA) using a simple covalent bond or a linker-mediated covalent bond to be effectively transferred into a cell, and is converted into nanoparticles by the hydrophobic interaction of the double-helical oligo RNA structure in a solution. It is desirable that the siRNA contained in the double-helical oligo RNA structure is a siRNA specific to a CTGF, Cyr61, or Plekho1, which are genes related to respiratory diseases, particularly idiopathic pulmonary fibrosis and COPD. In addition, the present invention relates to a method for producing the double-helical oligo RNA structure and a pharmaceutical composition containing the double-helical oligo RNA structure for preventing or treating respiratory diseases, particularly idiopathic pulmonary fibrosis and COPD.
