RESPIRATORY DISEASE RELATED GENE SPECIFIC SIRNA DOUBLE HELICAL OLIGO RNA STRUCTURE CONTAINING SIRNA COMPOSITON CONTAINING SAME FOR PREVENTING OR TREATING RESPIRATORY DISEASE
CHAE JEIWOOK,PARK HAN OH,YOON PYOUNG OH,HAN BORAM,KIM MI NA
申请号：
IN201617003548
公开号：
IN201617003548A
申请日:
2016.02.01
申请国别(地区):
IN
年份:
2016
代理人:
摘要：
The present invention relates to respiratory diseases especially to gene specific siRNA related to idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (COPD) and a highly efficient double helical oligo RNA structure containing the same wherein the double helical oligo RNA structure has a structure in which hydrophilic and hydrophobic materials are bonded at the both ends of the double helical RNA (siRNA) using a simple covalent bond or a linker mediated covalent bond to be effectively transferred into a cell and is converted into nanoparticles by the hydrophobic interaction of the double helical oligo RNA structure in a solution. It is desirable that the siRNA contained in the double helical oligo RNA structure is a siRNA specific to a CTGF Cyr61 or Plekho1 which are genes related to respiratory diseases particularly idiopathic pulmonary fibrosis and COPD. In addition the present invention relates to a method for producing the double helical oligo RNA structure and a pharmaceutical composition containing the double helical oligo RNA structure for preventing or treating respiratory diseases particularly idiopathic pulmonary fibrosis and COPD.
