YOON, PYOUNG OHKR,윤평오,KO, YOUNG HOKR,고영호,KIM, HAN NAKR,김한나,BAE, SEON JOOKR,배선주,LEE, JI YOUNGKR,이지영,YUN, SUNG ILKR,윤성일,PARK, JUN HONGKR,박준홍,JUNG, JUN SOOKR,정준수,CHOI, JONG DEOKKR,최종덕,KWON, TAE WOOKR,권태우
申请号：
KR1020160074570
公开号：
KR1020160147674A
申请日:
2016.06.15
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to breast cancer-related gene-specific siRNA, a high efficiency double-stranded oligo RNA structure including the same, and a pharmaceutical composition including the same for preventing or treating cancer. More specifically, the present invention relates to STAT3 gene-specific siRNA a double-stranded oligo RNA structure including the same, and having a structure in which a hydrophilic material and a hydrophobic material are combined by using a simple covalent bond or a linker-mediated covalent bond in both ends of double helix RNA (siRNA) to be effective transferred into cells a nano-particle capable of being produced by hydrophobic interaction of the double helix oligo RNA structure in a solution a method for producing the double helix oligo RNA structure and a pharmaceutical composition including the double helix oligo RNA structure for preventing or treating cancer, specifically, breast cancer, skin diseases, or inflammatory diseases. The STAT3 gene-specific siRNA and the composition including a double helix oligo RNA structure including the same for treating cancer, skin diseases, or inflammatory diseases inhibits the expression of STAT3 at high efficiency without causing side effects, so an effect in treating cancer, specifically, breast cancer, skin diseases including psoriasis, or inflammatory diseases can be ensured. Accordingly, the STAT3 gene-specific siRNA and the composition can be useful in treating breast cancer, skin disease, or inflammatory diseases which are currently difficult to be treated because there is not a suitable treating agent.COPYRIGHT KIPO 2017본 발명은 유방암 연관 유전자 특이적 siRNA 및 이를 포함하는 고효율 이중나선 올리고 RNA 구조체 및 이를 포함하는 암 예방 또는 치료용 약학적 조성물에 관한 것으로, 보다 구체적으로 STAT3 유전자 특이적 siRNA, 이를 포함하고, 세포 내로 효율적으로 전달되도록 하기 위하여 이중나선 RNA(siRNA)의 양 말단에 친수성 물질 및 소수성 물질을 단순 공유결합 또는 링커-매개(linker-mediated) 공유결합을 이용하여 접합된 형태의 구조를 가지는 이중나선 올리고 RNA 구조체, 수용액에서 상기 이중나선 올리고 RNA 구조체들의 소수성 상호작용에 의해 생성될 수 있는 나노입자, 상기 이중나선 올리고 RNA 구조체의 제조방법 및 상기 이중
