respiratory disease-related gene specific sirna, sirna-containing double-stranded oligo olna structure, a composition containing them to prevent or treat respiratory disease
BORAM HAN,HAN OH PARK,JEIWOOK CHAE,MI NA KIM,PYOUNG OH YOON
申请号：
BR112016000163
公开号：
BR112016000163A2
申请日:
2014.07.04
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
abstract gene specific sirna related to respiratory disease, double-stranded oligo oligo structure containing sirna, composition containing them to prevent or treat respiratory disease, refers to a specific sirna of respiratory disease-related gene, particularly a gene-specific siren with idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease (dpoc), and a highly efficient double-stranded oligo rna structure containing them, wherein the double-stranded oligo rna structure has a structure in which hydrophilic and hydrophobic materials are joined at both ends of the double-stranded (sirna) rna using a single covalent bond. or a binder-mediated covalent bond to be effectively transferred into a cell, and can be converted into nanoparticles by the hydrophobic interaction of the double-stranded oligo rna structure in a solution. It is desirable that the sirna contained in the double-stranded oligo rna structure be a ctgf, cyr61, or plekho1 specific sirna, which are genes related to respiratory diseases, particularly idiopathic pulmonary fibrosis. optical and dpoc. Furthermore, the present invention relates to a method for producing the double-stranded oligo rna structure and a pharmaceutical composition containing the double-stranded oligo rna structure to prevent or treat diseases. respiratory diseases, particularly idiopathic pulmonary fibrosis and dpoc. 1/1resumo sirna especêfico de gene relacionado ë doen‚a respiratîria, estrutura de oligo rna de dupla-hƒlice oligo contendo o sirna, composi‚ìo contendo os mesmos para prevenir ou tratar doen‚a respiratîria, refere-se a um sirna espec’fico de gene relacionado com doen�as respirat—rias, particularmente, a um sirna espec’fico de gene com fibrose pulmonar idiop‡tica e doen�a pulmonar obstrutiva cr™nica (dpoc), e uma estrutura de oligo rna de dupla hžlice altamente eficiente contendo os mesmos, em que a estrutura de oligo rna de dupla hžlice tem uma estrutura em que materiais hidrof’licos e hidrof—bicos s‹
