compound or a salt thereof, oligonucleotide analog, pharmaceutical composition, probe for a gene, primer to begin amplification, use of an oligonucleotide analog or a pharmacologically acceptable salt thereof, antisense agent, and antigen agent
"compound or salt thereof, oligonucleotide analog, pharmaceutical composition, probe for a gene, primer to begin amplification, use of an oligonucleotide analog or a pharmacologically acceptable salt thereof, antisense agent, and antigen agent". [subject] The object of the present invention is to provide novel oligonucleotide analogs which exhibit antisense or antigen activity having excellent stability, or exhibit excellent activity as a detection agent (probe) for a specific gene or as a primer to begin amplification, and to novel nucleoside analogues that are intermediate to their production. [solution] a compound of the formula (1): [wherein r 1 R 2 and r 2 are the same or different and represent a hydrogen atom, a hydroxyl protecting group, a phosphoric acid group, or -p (where ^ 3 ^ and ^ 4 ^ are the same or different and represent a hydroxyl group, an amino group, an alkoxy group having from 1 to 4 carbon atoms, a group cyanoalkoxy having from 1 to 5 carbon atoms or an amino group substituted by an alkyl group having from 1 to 4 carbon atoms]； a represents an alkylene group having from 1 to 4 carbon atoms； and b is a purin-9-yl group, a 2-oxo-pyrimidin-1-yl group or a substituted purin-9-yl group or a substituted 2-oxo-pyrimidin-1-yl group having a substituent selected from the following group <；244>；]； or its salt； (<；244>； group) a protected hydroxyl group, an alkoxy group having from 1 to 4 carbon atoms, a protected mercapto group, an alkylthio group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, a protected amino group, a mono or dialkylamino group which may be substituted by an alkyl group having from 1 to 4 carbon atoms, an alkyl group having from 1 to 4 carbon atoms and a halogen atom."composto ou um sal deste, análogo de oligonucleotídeo, composição farmacêutica, sonda para um gene, iniciador para começar a amplificação, uso de um análogo de oligonucleotídeo ou de um sal deste farmacologicamente aceitável, ag
