Общество с ограниченной ответственностью "НооГен" (RU)
发明人:
Стеценко Дмитрий Александрович (GB),Купрюшкин Максим Сергеевич (RU),Пышный Дмитрий Владимирович (RU)
申请号：
RU2014134380
公开号：
RU2014134380A
申请日:
2014.08.22
申请国别(地区):
RU
年份:
2016
代理人:
摘要：
1. The compound according to formula (I) in which the substituent Z is selected from —O, —S, —Se, —BH or —N (R), where R is H, C 1-6 alkyl or a protecting group； the substituent X is selected from the group consisting of 5 The '' end of the nucleoside, nucleoside analog, oligonucleotide, or oligonucleotide analog and Y substituent is selected from the group consisting of the 3 'end of the nucleoside, nucleoside analog, oligonucleotide, or oligonucleotide analog； -H, -OH, -SH, -NHR, -O-PG or S-PG, where PG is a protecting group； a linker, a monophosphate group or a diphosphate group, or a fluorescence label or quencher； or the Y substituent is selected from the group consisting of the 3 ′ end of a nucleoside, nucleoside analog, oligonucleotide, or oligonucleotide analog； -H, -OH, -SH, -NHR, -O-PG or S-PG, where PG is a protecting group； a linker, a monophosphate group or a diphosphate group, or a fluorescence label or quencher； the substituent R is selected from -NRR, -OR, -SR, -H, -S (O) H, -S (O) R, -S (O) H, —S (O) R, —S (O) NH, —S (O) NHR, —S (O) NR, —Calkyl, —Calkenyl, —Calkynyl, —Saryl or —Heteroaryl； the substituent R is selected from —H, - NRR, -OR, -SR, halogen, -CN, -S (O) H, -S (O) R, -S (O) H, -S (O) R, -S (O) NH, -S (O) NHR, —S (O) NR, —Calkyl, —Calkenyl, —Calkynyl, —Saryl or —Heteroaryl； where each of the substituents R, R, R and R is independently selected from the group consisting of: —H, —Calkyl, - Alkenyl, -Calkynyl, -Saryl or -Heteroaryl； where optionally R and R together form an alkylene or heteroal a kylen chain 2-4 atoms long； where optionally R and R, together with the atom with which they are bonded, form a 5-8 membered heterocycle； where optionally R and R, together with the atom with which they are bonded, form a 5-8 membered heterocycle； the substituent R is selected from —Salkyl, —Salkenyl, —Salkynyl, —Saryl, or —Heteroaryl； wherein each alkyl, aryl, heteroaryl, alkylene or heteroalkylene may be optionally substituted. 2. A compound accord
