University of Louisville Research Foundation; Inc.
发明人:
Ramesh C. Gupta,Radha Munagala,Farrukh Aqil,Jeyaprakash Jeyabalan
申请号：
US16531215
公开号：
US20190374467A1
申请日:
2019.08.05
申请国别(地区):
US
年份:
2019
代理人:
摘要：
A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.
