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Triazole derivatives as SCD inhibitors
专利权人:
GlaxoSmithKline LLC
发明人:
BOUILLOT, Anne Marie Jeanne,LAROZE, Alain
申请号:
ES08847760
公开号:
ES2575955T3
申请日:
2008.11.07
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula (I): ** formula ** wherein: X represents -CONH-, -NHCO- or -CH2NH-; R1 represents phenyl substituted with two independently selected groups of halogen; R 2 represents hydrogen, -C 1-6 alkyl or - (C 1-3 alkyl) -O- (C 1-3 alkyl); R3 represents: -C5-9 heteroaryl optionally substituted with 1, 2 or 3 groups independently selected from: -C1-3 alkyl, -C1-6 alkoxy, -CO2R4, -C (>; = O) NR5R6, -C (>; = O) NH- (C1-3 alkyl) -NR7R8, -C (>; = O) NH- (C1-3 alkyl) -O- (C1-3 alkyl), -C (>; = O) NH- (C1 alkyl -3) -OH, -C (>; = O) R9, - (C1-6 alkyl) -OH, -CHO, - (C1-3 alkyl) -CO2 (C1-3 alkyl), - (C1-3 alkyl ) -O- (C1-3 alkyl), -C1-6 haloalkyl, -O-C1-6 halogenoalkyl, C3-6 cycloalkyl, C3-6cycloalkyl, or halogen, wherein C5-9 heteroaryl means a aromatic cyclic group containing 5 to 9 ring atoms, 1, 2, 3 or 4 of which are heteroatoms independently selected from nitrogen, oxygen and sulfur and the rest of the ring atoms are carbon; R4 represents -H or -C1-3 alkyl; R5 represents -H or -C1-3 alkyl; R6 represents -H or -C 1-6 alkyl; R7 represents -H or -C1-3 alkyl; R8 represents -H or -C1-3 alkyl; and R9 represents -C6 heterocycle which is optionally substituted with a group independently selected from: -C1-6 alkyl, wherein C6 heterocyclyl refers to a cyclic group containing 6 ring atoms, 1, 2 or 3 of which are heteroatoms independently selected from nitrogen, oxygen and sulfur and the rest of the ring atoms are carbon; or one of its pharmaceutically acceptable salts.Un compuesto de fórmula (I):**fórmula** en donde: X representa -CONH-, -NHCO- o -CH2NH-; R1 representa fenilo sustituido con dos grupos independientemente seleccionados de halógeno; R2 representa hidrógeno, -alquilo C1-6 o -(alquil C1-3)-O-(alquilo C1-3); R3 representa: -heteroarilo C5-9 opcionalmente sustituido con 1, 2 o 3 grupos independientemente seleccionados de: -alquilo C1-3, -alcoxi C1-6, -CO2R4, -C(>;=O)NR5R6, -C(>;=O)NH-(alquil C1-3)-NR7R8, -C(>;=O)NH-(alquil C1-3)-O-(alquilo C1-3)
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中国工程科技知识中心
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