Nicolas Baurin,Francis Blanche,Béatrice Cameron,Tarik Dabdoubi,Jeremy Fordham,Dorothea Kominos,Jacintha Norohna,Tim Soos
申请号：
US13611789
公开号：
US20130108641A1
申请日:
2012.09.12
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention provides antibodies that specifically bind to human GITR (hGITR) with high affinity and antagonize the binding of hGITRL to hGITR. The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-GITR antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies of the invention to detect hGITR or to modulate hGITR activity, either in vitro or in vivo, are also provided by the invention.
