PROF. DR. LEE JEEWOO,DR. CHRISTOPH THOMAS,DR. LESCH BERNHARD,DR. FRANK ROBERT
申请号：
ARP120102685
公开号：
AR087302A1
申请日:
2012.07.25
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
As acyclic aza derivatives of the vanillin receptor alliance, they contain the pharmaceutical components of these compounds, as well as those compounds used in the treatment and / or prevention of pain and disease and / or other disorders.N for 1, 2, 3 or 4； X for N or CH； O, s or n-cn； Z for N or c-r4b； A1 for N or Cr5； A2 for N or Cr6； A3 for N or CR7； A4 for N or CR8； A5 for N or CR9； provided that A1, A2, A3, A4 and A5 represent nitrogen atoms； R0 represents 1 to 10 unreplaced carbon atoms or single atom or multi replaced carbon atoms； 3 to 10 carbon atoms； or 3 to 10 members,In each case, a single or a single that has not been replaced or fused can be selected to form a bridge, forming a troposphere composed of 1 to 8 carbon atoms, and the troposphere may not be replaced or single or polymerized； in each case, no replacement or single or polymer； in each case, a bridge can be selected to form a bridge. One to eight carbon atom alifaryl group, which can be unreplaced, single or polymerized； R1 represents one to four carbon atom alifaryl residues, unreplaced, single or polymerized； three to six carbon atom cyclic residues； or three to six member heterocyclic residues,In each case, unreplaced or PVC； R2 for R0； or0； sr0； NH2； nhr0 or n (R0) 2； R3 for H or crystalline residues of 1 to 4 carbon atoms or monomers or polymerized carbon atoms that are not replaced or not replaced； R4A for H； 1 to 4 crystalline residues of carbon atoms that are not replaced or polymerized； and one cycloaromatics residue. 3-6 carbon atoms； unreplaced monomer or polymer； unreplaced arilo or monomer or polymer； r4b represents h； or crystal residue, monomer or polymer of unreplaced 1-4 carbon atoms；Or R4A and r4b, together with the carbon atoms connecting them, form a ring-shaped residue composed of 3 to 6 unreplaced carbon atoms or single or polymerized carbon atoms； R5, R6, R7, R8 and R9 are independent,O) 2-N (R0)； N H 2； nh2-r0； NN（R0）2；NH-C（=O-R0）；NH-C（=O-o-R0；NH-C（=O-O-O-R0）；NH-C（=O-C
