These compounds can be used to treat and prevent diseases that may be affected by infected people, such as new and old metabolic diseases, especially type II diabetes. Requirement 1: a compound characterized by formula (1), wherein (HET) AR is connected by carbon atom and selected from the group (HET) ar-g1 composed of phenyl, Nafilo and a single ring or double ring heteroaromatic group are composed of 5 to 10 atoms in the ring, of which 2 to 9 members in the ring are carbon atoms. No matter a member in the ring, it is an unsubstituted or substituted heteroatom selected from n, NH, NRN, O, S,S (= O) and S (= O) 83222；Or one member of the ring is n, and the second member of the ring is selected from n, NH, NRN, O, s (= O) and S (= O) 832222,Or the two members of the ring are n, and the third member of the ring is selected from n, NH, NRN, O, s (= O) and S (= O) 83222；Or in nafilo, the ring not attached to the atom of indanil-o equation (1) may be partially saturated, in two ring heteroaromatics, the ring not attached to the atom of indanil-o equation (1) may be partially saturated, and at least one aromatic ring contains one heteroatom, As an alternative, some or all of the rings on the saturated bridge are replaced by N, NH, NRN, O, s (= O) or s (= O) 83222；The ring on the saturated bridge is replaced by N, NH or NRN, and the second ring is replaced by NH, NN, O, s, C (= O).S (= O) or s (= O) 83222；Or the members of two nonadjacent rings on a saturated bridge are replaced by O atoms, and any group is replaced by one to five R1 groups；R1 was selected from the group consisting of F, Cl, Br, I, CN, no832222；NH.8322；alquilo C--NH-,(Alquilo C) N-1. Lease of c83218331 and 83242431；C₂₋₄- alkenyl,1. C 83228331 asphalt；OH, HO-alquilo C₁₋₄,1. C83218331 - i.e. -,C₁₋₄-O-C₁₋₄ alkyl,1. C83218331-83242431-s -,alquilo C -S (3DO) -alquilo C -S (3DO) -C₃₋₆- cycloalkyl,-o-,wherein any alkyl or cycloalkyl group or sub-residue is optionally substituted with 1 to 5 F atoms； and RN is sel
