DART, Michael J.,CARROLL, William A.,FLORJANCIC, Alan S.,FROST, Jennifer M.,GALLAGHER, Megan E.,KOLASA, Teodozyj,LI, Tongmei,NELSON, Derek W.,PATEL, Meena V.,PEDDI, Sridhar,PEREZ-MEDRANO, Arturo,RYTHE
申请号：
ES07797908
公开号：
ES2645995T3
申请日:
2007.05.31
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound according to formula (I), ** Formula ** or a pharmaceutically acceptable salt, or a combination thereof wherein R 1 is alkyl, alkenyl, alkoxyalkyl, alkoxyalkoxyalkyl, alkoxycarbonylalkyl, alkynyl, arylalkoxyalkyl, arylalkyl, aryloxyalkyl, carboxyalkyl, cycloalkyl, cycloalkylalkyl, haloalkyl, haloalkoxyalkyl, heteroarylalkyl, heteroaryloxyalkyl, heterocycle, heterocycloalkyl, heterocyclooxyalkyl, hydroxyalkyl or RaRbNalkylene； R2 and R3, together with the carbon atoms to which they are attached, form a monocyclic ring of 4, 5, 6 or 7 members, optionally fused to a benzo or a monocyclic heteroaryl, said monocyclic ring contains zero or an additional double bond , an oxygen and zero atom or a nitrogen atom as ring atoms； two non-adjacent atoms of said monocyclic ring may optionally be linked by an alkenylene bridge of 2, 3 or 4 carbon atoms, or optionally linked by an alkylene bridge of 1, 2, 3 or 4 carbon atoms, said monocyclic ring is independently not substituted or substituted with 1, 2, 3, 4 or 5 substituents independently selected from the group consisting of oxo, alkyl, alkylsulfonyl, halo, -OH, -O (alkyl) and haloalkyl； two substituents on the same carbon atom of said monocyclic ring, together with the carbon atom to which they are attached, optionally form a 3, 4, 5 or 6 membered monocyclic cycloalkyl ring, wherein the monocyclic cycloalkyl ring is optionally substituted with 1, 2, 3, 4, 5 or 6 substituents independently selected from the group consisting of alkyl and haloalkyl； R4 is a bridge cycloalkyl or a bridge heterocycle； optionally substituted with 1, 2, 3, 4, 5 or 6 substituents selected from the group consisting of alkyl, -ORp, -NRcRd, oxo, halo, haloalkyl, carboxy and>； = CH2； where the bridge heterocycle has the formula (xxxii), (xxxiii), (xxxiv), (xxxv), (xxxvi) or (xxxvii) ** Formula ** and where the bridge cycloalkyl has the formula (xxiii) , (xxiv), (xxv), (xxvi), (xxvii), (xxviii), (xxix), (xxx) or (xxxi) ** Formula ** Ra and Rb a
