FUNDACIÓN CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS CARLOS III
发明人:
申请号：
ARP140100990
公开号：
AR095443A1
申请日:
2014.03.13
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Requirement 1: chemical entity selected from formula compound (1), wherein R1 is selected from arilo or hetero arilo； R2 is selected from NRC so8322；alkyl, cycloalkyl, aryl and heteroaryl； wherein R³ is independently selected in each case of H, alkyl optionally substituted with 1, 2 or 3 halo atoms, cycloalkyl optionally substituted with 1, 2 or 3 halo atoms and heterocycloalkyl optionally substituted with 1, 2 or 3 halo atoms ； and m is 1 or 2； alkyl is a linear saturated hydrocarbon having up to 10 C₁₋₁₀ carbon atoms or a branched saturated hydrocarbon of between 3 and 10 C₃₋₁₀ carbon atoms；cycloalkyl is a mono- or bi-cyclic saturated C₃₋₁₀ hydrocarbon, which may be optionally fused to an aryl group； or cycloalkyl is adamantyl； heterocycloalkyl is a C-linked or N-linked, 3-10 membered, saturated, mono- or bi-cyclic ring, containing 1, 2, 3 or 4 ring heteroatoms independently selected from N, S and O, wherein a N or S atom in the ring can be substituted with oxygen to form an N-oxide, sulfoxide or sulfone group； aryl is phenyl, biphenyl or naphthyl； and heteroaryl is a mono- aromatic ring,5. 6, 9 or 10, 12, 13 or 14 member double or three ring cycles, which may include 1, 2, 3 or 4 heteroatoms selected independently of N, s and O； and pharmaceutically acceptable salts, solutions, and stereoisomers of these compounds.Reivindicación 1: Una entidad química seleccionada de los compuestos de fórmula (1) en donde R¹ se selecciona de arilo o heteroarilo； R² se selecciona de NR³SO₂R³, alquilo, cicloalquilo, arilo y heteroarilo； en donde R³ se selecciona independientemente en cada caso de H, alquilo opcionalmente sustituido con 1, 2 ó 3 átomos de halo, cicloalquilo opcionalmente sustituido con 1, 2 ó 3 átomos de halo y heterocicloalquilo opcionalmente sustituido con 1, 2 ó 3 átomos de halo； y m es 1 ó 2； alquilo es un hidrocarburo saturado lineal que tiene hasta 10 átomos de carbono C₁₋₁₀ o un hidrocarburo saturado ramificado de entre 3 y 10 átomos de carbono C₃₋₁₀； cicloal
