SARA FRATTINI,ELKE LANGKOPF,MATTHIAS ECKHARDT,HOLGER WAGNER
申请号：
ARP130104569
公开号：
AR093864A1
申请日:
2013.12.06
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
These compounds are suitable for the treatment and prevention of diseases that may affect their recipients, such as new and old metabolic diseases, especially type 2 diabetes. Claim 1: a compound characterized by formula (1), wherein (HET) AR is connected by a carbon atom and selected from a group consisting of phenyl, naphthalene and a monocyclic or bicyclic heteroaromatic group consisting of 5 to 10 atoms, of which 2 to 9 members of the ring are carbon protons, and The members of the ring are the unsubstituted or substituted heteroatoms selected from n, NH, NRN, O, s, s (= O) and S (= O) 832222；Or one member of the ring is n, and the second member of the ring is selected from n, NH, NRN, O, s (= O) and S (= O) 832222；Or the two members of the ring are n, and the third member of the ring is selected from n, NH, NRN, O, s (= O) and S (= O) 832222；In naftelo, the optional indanil-o equation (1) is partially saturated with the unconnected ring of the atom, and in the heteroaromatic group of two rings, the optional indanil-o equation (1) is partially saturated with the unconnected ring of the atom, There is at least one heterogeneous aromatic ring. Optionally, on a partially or completely saturated bridge, N, NH, NRN, O, s (= O) or s (= O) 832222 replaces one component of the ring；The ring on the saturated bridge is replaced by N, NH or NRN, and the second ring is replaced by NH, NN, O, s, C (= O).S (= O) or s (= O) 83222；Or two nonadjacent rings on a saturated bridge are replaced by O atoms, any of which is replaced by 1r2 or 1NH group；In these groups, any group is replaced by 1-4 square brackets as an optional and independent way；O (HET) ar-g1 was selected as a group composed of 2, 3-dihydromin ol, 2, 3-dihydrohiisoindol, 2, 3-dihydrobenzofuran, 1, 3-dihydroisobenzofuran, benzo [1, 3] dioxol, 1, 2, 3, 4-tetrahydro-quinone, 1, 2, 3, 4-tetrahydro-isoquinone, croano, isochrome and 2, 3-dihydrobenzo [1, 4] dioxina, In formula (1), any one of these groups is linked to the
