Glucagon analogs that are potent activity in GIP receptor or multidimero; dimer; conjugate; Pharmaceutical composition that comprises; and their uses in treating diabetes or obesity.
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
WARD, BRIAN, D,DIMARCHI, RICHARD D.
申请号:
CL2013001783
公开号:
CL2013001783A1
申请日:
2013.06.18
申请国别(地区):
CL
年份:
2014
代理人:
摘要:
Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.ANÁLOGOS DE GLUCAGÓN QUE PRESENTAN ACTIVIDAD SOBRE EL RECEPTOR DE GIP, DÍMERO O MULTIDÍMERO, CONJUGADO, COMPOSICIÓN FARMACÉUTICA QUE LOS COMPRENDE, Y SU USO EN EL TRATAMIENTO DE DIABETES U OBESIDAD..