RAS INHIBITORY PEPTIDES AND USES THEREOF

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专利权人:

President and Fellows of Harvard College

发明人:

Gregory L. VERDINE,John Hanney MCGEE

申请号：

US16696027

公开号：

US20200239533A1

申请日:

2019.11.26

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention provides peptides comprising a sequence of X-6X-5X-4X-3X-2X-1X1PX3X4PX6X7PGX10X11AX13X14X15X16LX18X19X20X21X22X23LX25X26YLX29X30X31X32 (SEQ ID NO: 13) wherein the amino acids X−；6, X−；5, X−；4, X−；3, X−；2, X−；1, X1, X3, X4, X6, X7, X10, X11, X13, X14, X15, X16, X18, X19, X20, X21, X22, X25, X26, X29, X30, X31, and X32 are as defined herein. The present invention further provides pharmaceutical compositions comprising the peptides and methods of using the peptides for treating proliferative diseases such as cancer which are associated with Ras. Also provided are methods of screening a library of peptide dimers using a peptide dimer display technology.

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