FROST, Lisa,COURTNEY, Stephen,BROOKFIELD, Frederick,KALISH, Vincent
申请号：
ES09743703
公开号：
ES2601192T3
申请日:
2009.05.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound that is a nitrous derivative of formula VI or a pharmaceutically acceptable salt thereof: ** Formula ** wherein each R11a, R11b, R12a, R12b, R13a, R13b, R14a and R14b is H； and wherein D is selected from (i) the group consisting of C1-C8-C alkyl (O) -, perhaloalkyl-C (O) -, C2-C10-C alkenyl (O) -, C2-C10 alkynyl - C (O) -, aryl C6-C14-C (O) -, heteroaryl-C (O) - with a 5- or 6-membered ring, heterocyclyl-C (O) - with a 5- or 6-membered ring and -P (O) (C1-C8 Oalkyl) 2； wherein each alkyl, alkenyl and alkynyl is unsubstituted or substituted with 1 to 5 substituents independently selected from halo, nitro, cyano, oxo, C6-C14 aryl, C1-C8 alkoxy, C1-C8 alkoxycarbonyl, acyl, acyloxy, acylamino , amino, hydroxy, carboxyl, carboxy-C1-C8 alkyl, thiol, C1-C8 thioalkyl, heterocyclyl with a 5- or 6-membered ring and -OS (O) 2-C1-C8 alkyl and wherein each aryl, heteroaryl and heterocyclyl is unsubstituted or substituted with 1 to 5 substituents independently selected from halo, nitro, cyano, oxo, C6-C14 aryl, C1-C8 alkoxy, C1-C8 alkyl, acyl, acylamino, amino, hydroxyl, carboxyl, carboxy-alkyl C1-C8, thiol, C1-C8 thioalkyl, heterocyclyl with a 5- or 6-membered ring and -OS (O) 2-C1-C8 alkyl 2 0 (ii) C1-C4-C (O) alkyl - substituted where the substitution is one or more substituents selected from acyloxy, CH3OCH2CH2OCH2C (O) O-, (acetyl-OCH2) 2CHN (acetyl) -, (acetylCH2) 2CHN (Me) -, t-BuOC (O) NH-, PhCH2OC (O) NH- and alkoxycarbonyl C1-C8； and (iii) a remainder of the formulaUn compuesto que es un derivado nitroso de fórmula VI o una sal farmacéuticamente aceptable del mismo: **Fórmula** en la que cada R11a, R11b, R12a, R12b, R13a, R13b, R14a y R14b es H； y en la que D se selecciona de (i) el grupo que consiste en alquil C1-C8-C(O)-, perhaloalquil-C(O)-, alquenil C2-C10-C(O)-, alquinil C2-C10- C(O)-, aril C6-C14-C(O)-, heteroaril-C(O)- con un anillo de 5 o 6 miembros, heterociclil-C(O)- con un anillo de 5 o 6 miembros y -P(O)(Oalquilo C1-C8)2； en el que cada alquilo, a
