This disclosure provides compositions that include a mixture of viral like particles (VLPs) expressing different individual influenza hemagglutinin (HA) proteins that elicit broadly reactive immune responses to a wide variety of influenza viruses. For example the composition can include at least two different influenza VLPs a first VLP comprising a first HA polypeptide and a second VLP comprising a second influenza HA polypeptide wherein the first and the second HA polypeptide are different subtypes and/or are from different influenza viruses and a pharmaceutically acceptable carrier and/or an adjuvant. Methods of using the disclosed polymeric influenza VLP compositions to stimulate an immune response against influenza viruses for example as a pre pandemic or a seasonal vaccine are provided.
