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POLYVALENT INFLUENZA VIRUS-LIKE PARTICLES (VLPS) AND USE AS VACCINES
专利权人:
发明人:
Jeffery K. Taubenberger
申请号:
US15317593
公开号:
US20170128562A1
申请日:
2015.05.08
申请国别(地区):
US
年份:
2017
代理人:
摘要:
This disclosure provides compositions that include a mixture of viral like particles (VLPs), expressing different individual influenza hemagglutinin (HA) proteins that elicit broadly reactive immune responses to a wide variety of influenza viruses. For example, the composition can include at least two different influenza VLPs, a first VLP comprising a first HA polypeptide and a second VLP comprising a second influenza HA polypeptide, wherein the first and the second HA polypeptide are different subtypes and/or are from different influenza viruses, and a pharmaceutically acceptable carrier and/or an adjuvant. Methods of using the disclosed polymeric influenza VLP compositions to stimulate an immune response against influenza viruses, for example as a pre-pandemic or a seasonal vaccine, are provided.
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