PHARMACEUTICAL COMPOSITION COMPRISING THE EXTRACTION OF KAEMPFERIA PARVIFLORA AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
KYONG EUK PROVINCIAL ATA;경상북도(농업기술원생물자원연구소장);안동대학교 산학협력단;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
SOHN, HO YONG,손호용,KWON, JUNG BAE,권중배,YOO, MYUNG SUK,유명숙,KIM, MI SUN,김미선,SOHN, HO YONGKR,KWON, JUNG BAEKR,YOO, MYUNG SUKKR,KIM, MI SUNKR
申请号：
KR1020160051170
公开号：
KR1020170122065A
申请日:
2016.04.26
申请国别(地区):
KR
年份:
2017
代理人:
摘要：
The present invention relates to a pharmaceutical composition and a functional health food product for preventing or treating/alleviating thrombosis, comprising an extract of Kaempferia parviflora as an effective component. Specifically, the present invention relates to a pharmaceutical composition and a functional health food product for preventing or treating/alleviating thrombosis through potent inhibition on platelet aggregation and inhibition on blood coagulation, which comprise a hexene or ethyl acetate fraction of a hot water extract of Kaempferia parviflora, and an ethyl acetate fraction of an ethanol extract of Kaempferia parviflora as effective components. The extract of Kaempferia parviflora, as an effective component of the pharmaceutical composition and the functional health food product of the present invention, shows potent antithrombotic activity through an inhibition effect on platelet aggregation which acts as an initiator of thrombus formation, along with an inhibition effect on thrombus formation-related enzymes and blood coagulation factors. Additionally, the extract of Kaempferia parviflora shows no hemolytic activity to human red blood cells； has excellent thermal stability； and does not exhibit a decrease in inhibition activities on blood coagulation factors and thrombus formation-related enzymes even in an acid environment at pH 2 and in blood plasma, and thus may be used for preventing and treating/alleviating thrombosis such as ischemic stroke and hemorrhagic stroke through improving blood circulation. Additionally, the effective component can be processed in various forms such as extract, powder, pills, and tablets that can be conveniently ingested at all time, and thus are extremely useful in drug and food industries.본 발명은 흑생강(Kaempferia parviflora) 추출물을 유효성분으로 함유하는 혈전증(thrombosis)의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한 것으로서, 보다 구체적으로는, 흑생강 열수 추출물의 헥센 분획물 또는 에틸아세테이트 분획물과 흑생강 에탄올 추출물의 에틸아세테이트 분획물을 유효성분으로 하는 강력한 혈소판 응집 저해 및 혈액 응고 저해를 통한 혈전증의
