McRae, Stuart,Bowerman, Wendy E.,Braun, Steven Wilson,Spiehl, Regina,Messier, Bernadette,Farquhar, David,Koch, Erin Melissa,O'Leary, Jeremiah Peter,Fisher, Mark James,Kascak, Uros,Lantz, Loren J.,Nova
申请号：
ES13183578
公开号：
ES2622555T3
申请日:
2008.01.22
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A transdermal permeant administration system for administration of at least one permeant within a tissue membrane of a subject, comprising: a disposable substrate (40) having an upper substrate surface (42), and defining a poration area , comprising the disposable substrate (40) comprising a matrix of filaments (70) having a plurality of filaments (72) that are arranged in the poration area, where each filament (72) is configured to form a micropore in the tissue membrane； a first removable liner (110) having an upper surface (112) and an opposite lower surface (114), wherein at least a portion of the lower surface (114) of the first removable liner (110) is connected to the upper surface substrate (42)； and a patch (100) that can be selectively removed from the upper surface (112) of the first removable liner (110) comprising: a support layer (102) having an upper surface (105) and an opposite lower surface (106 )； and a reservoir (104) mounted on it a part of the lower surface (106) of the support layer (102) and which is configured to releasably contain at least one permeant； wherein, in a connected position, a first part (107) of the support layer (102) is detachably mounted on the upper surface (112) of the first removable liner (110) in spaced alignment with the poration area of the substrate (40), and where, in the connected position, a second part (108) of the support layer (102) is folded in a folded position, in which the bottom surface (106) of the second part ( 108) of the support layer (102) is facing in the opposite direction to the upper substrate surface (42) of the substrate (40), wherein the filament matrix (70) is mounted to a portion of the upper substrate surface (42), and wherein the substrate (40) further comprises a support (74) that is configured to be mounted on and superimposed on an upper surface (71) of the filament matrix (70) such that a part of the filament matrix (70) in the area of poration is exposed, and where The filament matrix
